Alzheimer’s disease is the most prevalent form of neurodegenerative disease, a group of conditions associated with the gradual loss of brain cells. These cells, also known as neurones, can undergo unfavourable processes and become dysfunctional and misfolded, ceasing to function at their full potential. Misfolded proteins are more likely to stick to each other and form a dangerous build-up of defective proteins. This is because changes in their structure exposes their sticky properties, making them more likely to stick to each other and accumulate in the body, a phenomenon known as protein aggregation.
In Alzheimer’s disease, the primary defective proteins are known as amyloid-beta and hyperphosphorylated tau protein. The accumulation of these defective proteins leads to sticky amyloid-beta plaques and neurofibrillary tangles. These plaques and tangles deposit in the brain and can obstruct important neurone-to-neurone communication, ultimately leading to neuronal death and structural changes in the brain. The presence of neurofibrillary tangles and amyloid-beta is a hallmark characteristic seen in Alzheimer’s disease.
How can Abbexa help?
Abbexa is proud to offer an extensive range of products to support research into Alzheimer’s disease. Being a dedicated worldwide supplier of biological tools for the life science, pharmaceutical development and biotechnology sectors, Abbexa provides the scientific community with kits and tools designed for use in research.
