Researchers from the University of Bath and Keele University have developed a groundbreaking composite material that could pave the way for new treatments targeting nervous system injuries and neurodegenerative conditions, such as Alzheimer’s and Parkinson’s disease.
The material, formed from cellulose and piezo-ceramic particles, acts as a scaffold for neural stem cells (NSCs), allowing precision delivery to affected areas. The study, published in Cell Reports Physical Science, describes how the 3D piezoelectric cellulose composite – created using directional freeze casting – stimulates neural stem cell growth through its piezoelectric properties.
“This is a groundbreaking biomaterial,” said Dr Hamideh Khanbareh, senior lecturer at the University of Bath’s Department of Mechanical Engineering. “It has the potential to redefine recovery prospects for central nervous system injuries and neurodegenerative diseases. Patients could regain life-changing functions, and clinicians could develop entirely new therapeutic tools.”
Beyond its medical promise, the composite is both sustainable and biodegradable. Its cellulose base breaks down naturally within the body after use, while the piezoelectric ceramic particles generate electrical charges under stress or movement, aiding stem cell stimulation.
The researchers envision personalised treatments using this technology. Lead investigator Dr Vlad Jarkov explained: “A CT scan could model a precise 3D implant tailored to a patient’s specific injury, bridging gaps in the brain or spinal cord.”
The development involved a multidisciplinary team of experts in mechanical engineering, chemistry, neuroscience, and materials science. Dr Jarkov cautioned that the technology remains in early stages: “Further testing, material optimisation, industrial scaling, and regulatory approval are necessary before this can reach hospitals. However, this is a promising step toward helping millions affected by life-altering brain and spinal cord injuries worldwide.”
The project received funding through the Hughes PhD scholarship, supported by University of Bath alumni and the Institute for Sustainable and Circular Technologies (ISCT).
Read the full story here.
